Autonomous Closed Loop Control of Fed-batch Bioreactors

Join this interactive session hosted by Kiefer Eaton, Co-Founder and Chief Customer Officer at Basetwo, for a walkthrough of a flagship autonomous control initiative developed in collaboration with CPI and Labman for a biosimilar fed-batch process.

Feeding decisions in lab-scale bioreactors usually rest on manual glucose, cell viability and assay data taken once a day. The team paired Labman's robotic sampling with Basetwo's model predictive control, which estimates nutrient demand continuously from the process tags CPI already logs and sets the feed automatically. It ran autonomously, without human intervention, for about three weeks.

The panel will cover why the sampling gap matters, what it took to trust a model with the feed, what the results showed, and where model-based PAT fits alongside Raman and NIR as teams move toward autonomous labs.