Maximum Quality at Maximum Speed - A Novel Approach to Freeze-Drying Cycle Design (on-demand)

In this webinar, Prof. Wolfgang Friess will introduce you to the field of pharmaceutical freeze-drying with a focus on process design. He will outline the critical phases of a freeze-drying cycle and present the impact of formulation aspects and process settings on the product quality.

Next, Dr. Brecht Vanbillemont will elaborate on a novel freeze-drying cycle design approach recently established at Coriolis Pharma. The approach applies a design space of the primary drying phase, which guarantees maximum product quality. Dr. Vanbillemont will explain the major sources of process variability in the primary drying phase and will apply that knowledge to design robust protocols. He will showcase the model-based optimization strategy by presenting two distinct case studies.

You will learn about...

• the basic aspects of lyophilization/freeze-drying process
• the impact of formulation and process settings on product quality
• sources of variability in the lengthy primary drying phase
• a novel strategy established at Coriolis Pharma to design robust and fast cycles