About this event
Chromatin regulators often require multiple binding events, involving DNA, the nucleosome core, histone post-translational modifications (PTMs) and other protein / nucleic acid elements: a concept known as multivalency. Dissecting this complexity demands highly defined, physiologically relevant experimental strategies. To this end we have pioneered access to fully defined nucleosomes and use these tools to functionally dissect chromatin factors and yield maximal insight from genomic mapping. Our studies highlight the importance of an unbiased interrogation of chromatin mechanisms at the nucleosomal level where multiple elements of the 'histone code' are revealed.
Hosted by
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Team member
Michael-Christopher Keogh CSO @ EpiCypherT
Dr. Keogh earned his PhD from Imperial College London and completed postdoctoral studies in London and at Harvard Medical School. His research has focused on technology development, genetic networks, and chromatin function / epigenetic regulation.
EpiCypher
For Scientists, By Scientists.EpiCypher leads in chromatin mapping with its CUTANA® platform for ultra-sensitive ChIC, CUT&RUN, and CUT&Tag assays. We offer the largest collection of defined designer nucleosomes (dNucs), along with high-throughput assays and expert services to support researchers globally.
