Single-cell DNA Damage Analysis Reveals Selective Genome Vulnerability

Hosted By: EpiCypher. Inc.

Guest Speakers: Chenxu Zhu, PhD | Christopher Hartl, Ph.D.

Join our upcoming webinar, presented in partnership with Epigenome Technologies, to learn how Paired-Damage-seq enables simultaneous profiling of oxidative DNA damage and the transcriptome. Paired-Damage-seq is a groundbreaking single-cell multiomics method that employs CUT&Tag to directly target regions of DNA damage within the genome, revealing cell-type-specific damage patterns linked to epigenetic states and offering new insights into disease mechanisms.

In this webinar, you will learn about:

• The challenges with existing approaches to studying DNA damage in single cells
• The fundamentals of Paired-Damage-seq, a scalable single-cell multiomics platform that utilizes a “labeling-by-repair” strategy and combinatorial indexing to simultaneously capture oxidative/single-stranded DNA damage and the transcriptome within the same cell
• How to get started with the experimental workflow of Paired-Damage-seq and its integration with additional multimodal single-cell datasets
• Potential new applications in neurodegeneration, cancer, and aging research by identifying cell-type-specific “vulnerability hotspots”
• This webinar will be of interest to researchers in genomics, epigenetics, single-cell biology, and disease biology who are looking to expand their toolkit for studying genome instability.

Suggested Audience: This webinar will be of interest to researchers in genomics, epigenetics, single-cell biology, and disease biology who are looking to expand their toolkit for studying genome instability.