Nuclera invites you to their event

Defying Difficult-to-Express Proteins: Overcoming Protein Expression Challenges

About this event

Introduction:

In this webinar, we will explore how the eProtein Discovery™ platform addresses the challenges of expressing difficult-to-express proteins, such as transcription factors, proteins with disordered regions and disulfide bonds. Leveraging advanced cell-free protein synthesis (CFPS) and digital microfluidic technology, this system enables researchers to rapidly produce soluble, purified proteins within 48 hours. Using case studies, we will demonstrate how insights from expression and purification screening can be used to guide scale up protein production in cell-based systems. This seamless transition allows for the production of functional proteins from microgram/sub-milligram to milligram quantities. This webinar will showcase how this technology revolutionizes protein expression, accelerating therapeutic development and advancing protein research.

Webinar Topics:

  • Accelerating Protein Production: The eProtein Discovery™ system enables rapid, automated screening and production of difficult-to-express proteins, resulting in soluble, functional proteins within just 48 hours.
  • Case Studies: Real-world examples showcasing the successful expression of challenging proteins, such as transcription factors, through cell-free protein synthesis (CFPS).
  • From Cell-Free to Cells: Demonstrating how cell-free expression insights can be applied to cell-based systems, enabling scalable protein production from microgram/sub-milligram to milligram quantities of functional proteins.

What to expect?

  • Mastering Complex Protein Expression: Gain practical insights into how the platform simplifies the production of proteins with complex structures, including those with disulfide bonds and disordered regions.
  • End-to-End Scalability: Understand how eProtein Discovery™ facilitates seamless transitions from scalable cell-free protein production to in-cell systems, empowering researchers to accelerate their workflows and increase protein yields.
  • Real-World Applications: See firsthand how advanced automation and protein synthesis technologies are applied in real-world scenarios, offering solutions to difficult protein expression problems and driving faster therapeutic research and discovery.

Hosted by

  • Team member
    RT T
    Ruben Tomas Field Application Scientist @ Nuclera
  • Team member
    YT T
    Yvonne Tan

Nuclera

Nuclera empowers researchers to accelerate discovery with rapid, in-house access to high-quality functional proteins.