RedTalks #3: "Genetics proposes, Epigenetics disposes”. But in lymphomas, it's all in the genes...

CALYM Institute launches its RedTalks, a Series of scientific Webinars

RedTalks #3: Genetics-driven epigenetic dysfunction in germinal center derived B cell lymphomas

Laura Pasqualucci, MD - Institute for Cancer Genetics, Columbia University New York, NY, USA

Dr. Pasqualucci’s research interests focus on the molecular pathogenesis of B cell malignancies, with emphasis on its most common types, diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). The laboratory takes advantage of genomic profiling approaches and genetically modified mouse models to identify and functionally characterize the genetic lesions that are associated with these cancers, as a tool to better understand the mechanisms that are responsible for the initiation and maintenance of the tumor cell. The ultimate goal is to develop improved biomarkers and more effective treatment options for lymphoid malignancies.

In this RedTalk, Dr. Pasqualucci will discuss the unique link between the physiologic germinal center reaction and the pathogenesis of B cell lymphomas, and illustrate how genetic alterations in epigenetic modifier genes contribute to the making of these tumors, and present potential therapeutic implications.

👉 More information on lymphoma-research-experts.org/calym