HOW TO GET A REPRESENTATIVE SAMPLE IN CHEMICAL & POLYMERS (PART II): PAT (NIR) approach for process monitoring: Issues and challenges.

Based on the Theory of Sampling (TOS) webinar for Chemical & Polymers presented earlier by ProcessControlExpert, this is a direct follow-up focusing on Process sampling: "How to extract representative samples from a moving stream of heterogeneous matter".

It is shown how there is a complete *duality* between sampling of stationary lots and of dynamic lot, as both are governed by the same Governing Principles (GP), Sampling Unit Operations (SUO) and identical rules for Sampling Error Management (SEM).

This webinar has a particular focus on the *sampling interface*, which is the critical success factor for application of PAT sensor technology, illustrated by selected examples and case histories. Also for process sampling, TOS is shown to be a necessary requirement for:

• Eliminating, or reducing, hidden economic losses due to non-representative analytical results
• Improving process understanding and efficiency (better on-line sampling, monitoring and control)
• Reducing raw materials and energy waste (by unbiased sampling accuracy and precision)
• Understanding how TOS is a missing link in Risk Assessment
• Increasing company professional credibility and reputation - and ultimately increasing ROI

If you didn't follow the previous webinar on sampling in Pharma, please feel free to subscribe to the next session which would be held on by clicking here: "HOW TO GET A REPRESENTATIVE SAMPLE (PART I): SAMPLING SCIENCE & TECHNOLOGY APPLIED TO CHEMICAL & POLYMERS"

This 60 minute webinar (10-15 min for Q&A) is presented by prof. Kim H. Esbensen, Ph.D., Dr. (h.c.), Denmark. Participants receive a comprehensive introductionary documentation (1,2), also allowing deeper self-education (3,4):

1. "The sampling interface - a critical success factor in PAT and process monitoring" (Esbensen & Sivalingam)

2. "Pierre Gy’s development of the Theory of Sampling: a retrospective summary -with a didactic tutorial on quantitative sampling of one-dimensional lots" (Minnitt & Esbensen)

3. "Adequacy and verifiability of pharmaceutical mixtures and dose units by variographic analysis (Theory of Sampling) – A call for a regulatory paradigm shift" (Esbensen & Romañach)

4. "Proper sampling, total measurement uncertainty, variographic analysis & fit-for-purpose acceptance levels for pharmaceutical mixing monitoring" (Esbensen & Romañach)