Mordernizing GCMS Workflows: Session 1 - 3

Session 1: Reliable VOC Preparation and Temporal Control

In high-throughput GC/MS analysis, a critical yet frequently overlooked source of technical variation is the inconsistent "waiting time" between sample preparation and injection. When samples are processed in manual batches, the interval between the completion of a reaction and the moment of injection varies across the set.

Headspace analysis is the backbone of GC. This session focuses on modernizing the VOC workflow for water analysis by implementing robotic precision. We demonstrate how sequential liquid handling and automated injection phases move your lab from manual uncertainty to a system that delivers consistent, reproducible data through identical sample-to-sample timing.

Join Dr. Daniela Cavagnino from Thermo Fisher Scientific and Dr. Hagen Gegner in this application-focused deep dive.

Session 2: Sequential Derivatization for Clinical Consistency

In clinical metabolomics, derivative stability and manual sample preparation are major drivers of technical noise and experimental bias. Guest speaker Dr. Akrem Jbebli (RECETOX) joins us to demonstrate how modernizing blood analysis workflows with automated, sequential derivatization can conquer these challenges to deliver robust GC-Orbitrap metabolomics data. We will examine the standardization of automated, two-step in-vial derivatization protocols that bring strictly controlled conditions to routine sample-to-sample workflows for dried blood spots (DBS), serum, and plasma. Akrem will share detailed methods, QA/QC practices, and reproducibility datasets, showcasing how documenting and replicating every step of sample preparation ensures reliable biological insights. All resources and datasets from this study will be shared to support future field development.

Session 3: Sustainable SVOC Analysis and Automated Extraction

Liquid-liquid extraction (LLE) is a significant source of pre-analytical noise due to inconsistent manual handling. We showcase how to modernize this workflow by replacing manual extraction with robotic micro-LLE. By automating the extraction process sequentially, we significantly reduce technical variation and solvent consumption while maintaining full EPA 8270 compliance. Join Dr. Daniela Cavagnino from Thermo Fisher Scientific and Dr. Hagen Gegner in this EPA-compliant deep dive.

This three-part webinar series is a collaborative effort between PAL System, Thermo Fisher Scientific, and Recetox.

We want to thank all speakers and behind-the-scenes helpers for making this possible!