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Spatial transcriptomics and multiomics in cancer research

About this event

Spatial context matters in complex biology.

From cancer prevention to cancer biology, and for both translational and clinical studies, multiomic spatial biology is proving to be an exceptional tool to answer new questions and accelerate results.

In this webinar, the winner of the Spatial Biology EACR & NanoString Grant program, in collaboration with Illumina, will present their cancer research study as they unravel biological complexity in the immune landscape in brain metastasis using spatial technologies.

In situ spatial transcriptomics, powered by GeoMx® Digital Spatial Profiler, allows you to decide where to draw the line in choosing the tissue microenvironments and cell types that matter most for your research projects. Allowing the tissue sample to be the guide means it is possible to gather accurate information about spatial relationships among populations of cells, and ultimately uncover novel and effective clinical treatments.

Are you in search of innovative biomarkers, new drug targets, or distinctive gene and protein signatures?

Join this webinar to:

  • Gain perspective on the heterogeneity of immune response and understand how it is impacted by the tumour microenvironment.
  • Obtain new ideas, approaches and lessons learned relating to whole transcriptome spatial analysis as well as spatial multiomics work from recent publications.
  • Learn from your peers how you can get a complete picture of biology at any scale, with multi-analyte profiling, highest plex and spatial context.
  • Discover how you could uncover the next Immuno-Oncology biomarker with the new +570 protein GeoMx® IO Proteome Atlas (IPA).

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Talks

NanoString spatial biology solutions – discover where biology happens

- Rudy Van Eijsden, NanoString Technologies

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Enabling multiomics

- Vivek Kumar Mishra, Illumina

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Case study: Exploring the spatial context of tumour microenvironment evolution upon radiotherapy and adenosine blockade in brain metastasis

- Anna Salamero Boix, Georg-Speyer Haus, Frankfurt

Abstract: Brain metastasis is an unmet clinical need in high demand for novel and effective treatments. In preclinical brain metastasis models, we found that combining radiotherapy with adenosine blockade leads to better tumour control. We leveraged the GeoMx® DSP platform to spatially characterize the cellular and molecular dynamics of the murine brain metastasis tumour microenvironment upon radiotherapy and adenosine blockade. We observed treatment-specific alterations in the immune landscape and identified underlying pathways associated with anti-cancer immunity.

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Q&A with the speakers.

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This webinar has been produced with the kind support of NanoString Technologies and Illumina. You can find out more about the technologies used in the projects presented in this webinar by visiting the NanoString Technologies and Illumina websites.

Hosted by

  • Team member
    CH T
    Celine Hashwe Frontline Genomics

  • Guest speaker
    AS G
    Anna Salamero Boix

  • Guest speaker
    RV G
    Rudy Van Eijsden

  • Guest speaker
    AW G
    Agnese Winfield marketing sr director @ nanostring

  • Guest speaker
    VK G
    Vivek Kumar Mishra

  • Guest speaker
    SM G
    Sue Ann Molero

  • Guest speaker
    Av G
    Anna van der Valk

Front Line Genomics

Delivering the Benefits of Genomics to Patients Faster

Front Line Genomics is a genomics-focused media company, with a social mission to deliver the benefits of genomics to patients faster. We organise the Festival of Genomics, digital events and webinars. We also produce reports and operate a content-rich website.